Literature summary extracted from

Dewanjee, S.; Gangopadhyay, M.; Das, U.; Sahu, R.; Khanra, R.
Enhanced rosmarinic acid biosynthesis in Solenostemon scutellarioides culture: a precursor-feeding strategy (2014), Nat. Prod. Res., 28, 1691-1698.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.237	L-tyrosine	activates the enzyme	Coleus scutellarioides

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.237	additional information	cultures fed with precursors, namely L-Phe, L-Tyr, and cucumber juice, at different concentrations show Phe an 1.5, 2.1, and 1.6fold increase in rosmarinic acid accumulation within 48-72 h, respectively. In this study, we focused on the function of individual precursor on key enzymes involved in RA biosynthesis. The phenylalanine ammonia lyase activity was significantly upregulated after Phe feeding, while tyrosine aminotransferase and hydroxyphenylpyruvate reductase activities are improved with Tyr treatment. Rosmarinic acid synthase activity is significantly enhanced by all three precursors, overview	Coleus scutellarioides

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.237	Coleus scutellarioides	-	-	-

General Information

EC Number	General Information	Comment	Organism
1.1.1.237	metabolism	the key enzyme is involved in rosmarinic acid biosynthesis	Coleus scutellarioides

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Release 2023.1 (January 2023)